Evaluation of Pharmacological Profiling of Albizia Odoratissima Bark Extracts on Ethanol-Induced Hepatotoxicity in Albino Rats

Alcohol consumption is a common cause of acute and chronic hepatic toxicity in patients. Discovery novel therapeutic agents from medicinal plants most recommended because the presence diverse phytochemicals. The aim study to evaluate effect methanolic extract bark Albizia odoratissima on ethanol-induced hepatotoxicity rats. following objectives A. was screened for phytochemical analysis, tests hepatoprotection using an Albino rat model were conducted. Twenty-four male albino rats selected divided into four groups (n=6). Animals received treatments period 21 days. Normal control (Group-I) vehicles; toxic (Group-II) ethanol (2 ml/kg/p.o.). Treatment (Groups-III IV) Silymarin (50 mg/kg/p.o.) plant (250 mg/kg/p.o.). Biochemical parameters such as enzymes, biomarkers histopathology estimated assess severity injury or disease. Phytochemical analysis reported secondary metabolites. Ethanol significantly increased SGPT SGOT, ALP, TB, urea, creatinine decreased total protein albumin levels, indicating damage. ameliorates all enzymes compared hepatotoxic control. Meanwhile, only SGPT, creatinine, Histopathological examinations silymarin revealed reduced liver inflammation. This concludes that 250mg/kg dose showed partial protective effects with silymarin.